At present, pathological diagnosis of urine exfoliated cells is carried out both domestically and internationally. After obtaining urine, it is first settled and then centrifuged multiple times. Thin layer liquid based slide machines or manual smears are used for slide preparation, staining, and microscopic examination.
However, the amount of shed cells in urine is extremely low; During the inspection and centrifugation process, fresh cells are prone to adhere to the container, resulting in a significant loss of cells; Dropped cells in urine are prone to degeneration and dissolution in a short period of time; The capacity of clinical specimens for testing is limited; Less frequency of submission for inspection; These reasons result in the inability to obtain sufficient and fresh urine exfoliated cells to complete pathological diagnosis, leading to pathology technicians spending huge manpower and resources to repeatedly obtain patient urine, repeat large amounts of centrifugation and other operations, in order to produce pathological slides that meet the standards.
The new liquid based technology for bladder cancer can collect fresh and sufficient urine exfoliated cells by patients themselves, and prepare satisfactory thin layer liquid based slides of urine exfoliated cells, which can be used for early screening of normal people, diagnosis of abnormal people, and follow-up of patients.
